CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2
Identifieur interne : 000B83 ( Main/Exploration ); précédent : 000B82; suivant : 000B84CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2
Auteurs : Roy J. Soberman [États-Unis] ; Christopher R. Mackay [États-Unis] ; Christine A. Vaine [États-Unis] ; Glennice Bowen Ryan [États-Unis] ; Anna M. Cerny [États-Unis] ; Mikayla R. Thompson [États-Unis] ; Boris Nikolic [États-Unis] ; Valeria Primo [États-Unis] ; Peter Christmas [États-Unis] ; Paul Sheiffele [États-Unis] ; Lisa Aronov [États-Unis] ; David M. Knipe [États-Unis] ; Evelyn A. Kurt-Jones [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
The CD200R1:CD200 axis is traditionally considered to limit tissue inflammation by down-regulating pro-inflammatory signaling in myeloid cells bearing the receptor. We generated CD200R1−/− mice and employed them to explore both the role of CD200R1 in regulating macrophage signaling via TLR2 as well as the host response to an
Url:
DOI: 10.1371/journal.pone.0047740
PubMed: 23082204
PubMed Central: 3474780
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000707
- to stream Pmc, to step Curation: 000707
- to stream Pmc, to step Checkpoint: 000521
- to stream Ncbi, to step Merge: 000300
- to stream Ncbi, to step Curation: 000300
- to stream Ncbi, to step Checkpoint: 000300
- to stream Main, to step Merge: 000B85
- to stream Main, to step Curation: 000B83
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2</title><author><name sortKey="Soberman, Roy J" sort="Soberman, Roy J" uniqKey="Soberman R" first="Roy J." last="Soberman">Roy J. Soberman</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mackay, Christopher R" sort="Mackay, Christopher R" uniqKey="Mackay C" first="Christopher R." last="Mackay">Christopher R. Mackay</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Vaine, Christine A" sort="Vaine, Christine A" uniqKey="Vaine C" first="Christine A." last="Vaine">Christine A. Vaine</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ryan, Glennice Bowen" sort="Ryan, Glennice Bowen" uniqKey="Ryan G" first="Glennice Bowen" last="Ryan">Glennice Bowen Ryan</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Cerny, Anna M" sort="Cerny, Anna M" uniqKey="Cerny A" first="Anna M." last="Cerny">Anna M. Cerny</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Thompson, Mikayla R" sort="Thompson, Mikayla R" uniqKey="Thompson M" first="Mikayla R." last="Thompson">Mikayla R. Thompson</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Nikolic, Boris" sort="Nikolic, Boris" uniqKey="Nikolic B" first="Boris" last="Nikolic">Boris Nikolic</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Primo, Valeria" sort="Primo, Valeria" uniqKey="Primo V" first="Valeria" last="Primo">Valeria Primo</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Christmas, Peter" sort="Christmas, Peter" uniqKey="Christmas P" first="Peter" last="Christmas">Peter Christmas</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sheiffele, Paul" sort="Sheiffele, Paul" uniqKey="Sheiffele P" first="Paul" last="Sheiffele">Paul Sheiffele</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>InGenious Targeting Laboratory Incorporated, Stony Brook, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>InGenious Targeting Laboratory Incorporated, Stony Brook, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Aronov, Lisa" sort="Aronov, Lisa" uniqKey="Aronov L" first="Lisa" last="Aronov">Lisa Aronov</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>InGenious Targeting Laboratory Incorporated, Stony Brook, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>InGenious Targeting Laboratory Incorporated, Stony Brook, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Knipe, David M" sort="Knipe, David M" uniqKey="Knipe D" first="David M." last="Knipe">David M. Knipe</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kurt Jones, Evelyn A" sort="Kurt Jones, Evelyn A" uniqKey="Kurt Jones E" first="Evelyn A." last="Kurt-Jones">Evelyn A. Kurt-Jones</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23082204</idno><idno type="pmc">3474780</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474780</idno><idno type="RBID">PMC:3474780</idno><idno type="doi">10.1371/journal.pone.0047740</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000707</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000707</idno><idno type="wicri:Area/Pmc/Curation">000707</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000707</idno><idno type="wicri:Area/Pmc/Checkpoint">000521</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000521</idno><idno type="wicri:Area/Ncbi/Merge">000300</idno><idno type="wicri:Area/Ncbi/Curation">000300</idno><idno type="wicri:Area/Ncbi/Checkpoint">000300</idno><idno type="wicri:Area/Main/Merge">000B85</idno><idno type="wicri:Area/Main/Curation">000B83</idno><idno type="wicri:Area/Main/Exploration">000B83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2</title><author><name sortKey="Soberman, Roy J" sort="Soberman, Roy J" uniqKey="Soberman R" first="Roy J." last="Soberman">Roy J. Soberman</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mackay, Christopher R" sort="Mackay, Christopher R" uniqKey="Mackay C" first="Christopher R." last="Mackay">Christopher R. Mackay</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Vaine, Christine A" sort="Vaine, Christine A" uniqKey="Vaine C" first="Christine A." last="Vaine">Christine A. Vaine</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ryan, Glennice Bowen" sort="Ryan, Glennice Bowen" uniqKey="Ryan G" first="Glennice Bowen" last="Ryan">Glennice Bowen Ryan</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Cerny, Anna M" sort="Cerny, Anna M" uniqKey="Cerny A" first="Anna M." last="Cerny">Anna M. Cerny</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Thompson, Mikayla R" sort="Thompson, Mikayla R" uniqKey="Thompson M" first="Mikayla R." last="Thompson">Mikayla R. Thompson</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Nikolic, Boris" sort="Nikolic, Boris" uniqKey="Nikolic B" first="Boris" last="Nikolic">Boris Nikolic</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Primo, Valeria" sort="Primo, Valeria" uniqKey="Primo V" first="Valeria" last="Primo">Valeria Primo</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Christmas, Peter" sort="Christmas, Peter" uniqKey="Christmas P" first="Peter" last="Christmas">Peter Christmas</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Sheiffele, Paul" sort="Sheiffele, Paul" uniqKey="Sheiffele P" first="Paul" last="Sheiffele">Paul Sheiffele</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>InGenious Targeting Laboratory Incorporated, Stony Brook, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>InGenious Targeting Laboratory Incorporated, Stony Brook, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Aronov, Lisa" sort="Aronov, Lisa" uniqKey="Aronov L" first="Lisa" last="Aronov">Lisa Aronov</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>InGenious Targeting Laboratory Incorporated, Stony Brook, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>InGenious Targeting Laboratory Incorporated, Stony Brook, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Knipe, David M" sort="Knipe, David M" uniqKey="Knipe D" first="David M." last="Knipe">David M. Knipe</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kurt Jones, Evelyn A" sort="Kurt Jones, Evelyn A" uniqKey="Kurt Jones E" first="Evelyn A." last="Kurt-Jones">Evelyn A. Kurt-Jones</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The CD200R1:CD200 axis is traditionally considered to limit tissue inflammation by down-regulating pro-inflammatory signaling in myeloid cells bearing the receptor. We generated CD200R1<sup>−/−</sup> mice and employed them to explore both the role of CD200R1 in regulating macrophage signaling via TLR2 as well as the host response to an <italic>in vivo</italic>, TLR2-dependent model, herpes simplex virus 1 (HSV-1) infection. CD200R1<sup>−/−</sup> peritoneal macrophages demonstrated a 70–75% decrease in the generation of IL-6 and CCL5 (Rantes) in response to the TLR2 agonist Pam<sub>2</sub>CSK<sub>4</sub> and to HSV-1. CD200R1<sup>−/−</sup> macrophages could neither up-regulate the expression of TLR2, nor assemble a functional inflammasome in response to HSV-1. CD200R1<sup>−/−</sup> mice were protected from HSV-1 infection and exhibited dysfunctional TLR2 signaling. Finally, both CD200R1<sup>−/−</sup> mice and CD200R1<sup>−/−</sup> fibroblasts and macrophages showed a markedly reduced ability to support HSV-1 replication. In summary, our data demonstrate an unanticipated and novel requirement for CD200R1 in “licensing” pro-inflammatory functions of TLR2 and in limiting viral replication that are supported by <italic>ex vivo</italic> and <italic>in vivo</italic> evidence.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Creagh, Em" uniqKey="Creagh E">EM Creagh</name></author><author><name sortKey="O Eill, La" uniqKey="O Eill L">LA O’Neill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunne, A" uniqKey="Dunne A">A Dunne</name></author><author><name sortKey="O Eill, La" uniqKey="O Eill L">LA O’Neill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Medzhitov, R" uniqKey="Medzhitov R">R Medzhitov</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kurt Jones, Ea" uniqKey="Kurt Jones E">EA Kurt-Jones</name></author><author><name sortKey="Belko, J" uniqKey="Belko J">J Belko</name></author><author><name sortKey="Yu, C" uniqKey="Yu C">C Yu</name></author><author><name sortKey="Newburger, Pe" uniqKey="Newburger P">PE Newburger</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurt Jones, Ea" uniqKey="Kurt Jones E">EA Kurt-Jones</name></author><author><name sortKey="Chan, M" uniqKey="Chan M">M Chan</name></author><author><name sortKey="Zhou, S" uniqKey="Zhou S">S Zhou</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Reed, G" uniqKey="Reed G">G Reed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurt Jones, Ea" uniqKey="Kurt Jones E">EA Kurt-Jones</name></author><author><name sortKey="Belko, J" uniqKey="Belko J">J Belko</name></author><author><name sortKey="Yu, C" uniqKey="Yu C">C Yu</name></author><author><name sortKey="Newburger, Pe" uniqKey="Newburger P">PE Newburger</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lundberg, P" uniqKey="Lundberg P">P Lundberg</name></author><author><name sortKey="Ramakrishna, C" uniqKey="Ramakrishna C">C Ramakrishna</name></author><author><name sortKey="Brown, J" uniqKey="Brown J">J Brown</name></author><author><name sortKey="Tyszka, Jm" uniqKey="Tyszka J">JM Tyszka</name></author><author><name sortKey="Hamamura, M" uniqKey="Hamamura M">M Hamamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Jp" uniqKey="Wang J">JP Wang</name></author><author><name sortKey="Bowen, Gn" uniqKey="Bowen G">GN Bowen</name></author><author><name sortKey="Zhou, S" uniqKey="Zhou S">S Zhou</name></author><author><name sortKey="Cerny, A" uniqKey="Cerny A">A Cerny</name></author><author><name sortKey="Zacharia, A" uniqKey="Zacharia A">A Zacharia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitley, R" uniqKey="Whitley R">R Whitley</name></author><author><name sortKey="Arvin, A" uniqKey="Arvin A">A Arvin</name></author><author><name sortKey="Prober, C" uniqKey="Prober C">C Prober</name></author><author><name sortKey="Corey, L" uniqKey="Corey L">L Corey</name></author><author><name sortKey="Burchett, S" uniqKey="Burchett S">S Burchett</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Carr, Dj" uniqKey="Carr D">DJ Carr</name></author><author><name sortKey="Campbell, Il" uniqKey="Campbell I">IL Campbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vilela, Mc" uniqKey="Vilela M">MC Vilela</name></author><author><name sortKey="Mansur, Ds" uniqKey="Mansur D">DS Mansur</name></author><author><name sortKey="Lacerda Queiroz, N" uniqKey="Lacerda Queiroz N">N Lacerda-Queiroz</name></author><author><name sortKey="Rodrigues, Dh" uniqKey="Rodrigues D">DH Rodrigues</name></author><author><name sortKey="Lima, Gk" uniqKey="Lima G">GK Lima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melchjorsen, J" uniqKey="Melchjorsen J">J Melchjorsen</name></author><author><name sortKey="Paludan, Sr" uniqKey="Paludan S">SR Paludan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cook, Wj" uniqKey="Cook W">WJ Cook</name></author><author><name sortKey="Kramer, Mf" uniqKey="Kramer M">MF Kramer</name></author><author><name sortKey="Walker, Rm" uniqKey="Walker R">RM Walker</name></author><author><name sortKey="Burwell, Tj" uniqKey="Burwell T">TJ Burwell</name></author><author><name sortKey="Holman, Ha" uniqKey="Holman H">HA Holman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wright, Gj" uniqKey="Wright G">GJ Wright</name></author><author><name sortKey="Puklavec, Mj" uniqKey="Puklavec M">MJ Puklavec</name></author><author><name sortKey="Willis, Ac" uniqKey="Willis A">AC Willis</name></author><author><name sortKey="Hoek, Rm" uniqKey="Hoek R">RM Hoek</name></author><author><name sortKey="Sedgwick, Jd" uniqKey="Sedgwick J">JD Sedgwick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoek, Rm" uniqKey="Hoek R">RM Hoek</name></author><author><name sortKey="Ruuls, Sr" uniqKey="Ruuls S">SR Ruuls</name></author><author><name sortKey="Murphy, Ca" uniqKey="Murphy C">CA Murphy</name></author><author><name sortKey="Wright, Gj" uniqKey="Wright G">GJ Wright</name></author><author><name sortKey="Goddard, R" uniqKey="Goddard R">R Goddard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snelgrove, Rj" uniqKey="Snelgrove R">RJ Snelgrove</name></author><author><name sortKey="Goulding, J" uniqKey="Goulding J">J Goulding</name></author><author><name sortKey="Didierlaurent, Am" uniqKey="Didierlaurent A">AM Didierlaurent</name></author><author><name sortKey="Lyonga, D" uniqKey="Lyonga D">D Lyonga</name></author><author><name sortKey="Vekaria, S" uniqKey="Vekaria S">S Vekaria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Cherwinski, H" uniqKey="Cherwinski H">H Cherwinski</name></author><author><name sortKey="Sedgwick, Jd" uniqKey="Sedgwick J">JD Sedgwick</name></author><author><name sortKey="Phillips, Jh" uniqKey="Phillips J">JH Phillips</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mihrshahi, R" uniqKey="Mihrshahi R">R Mihrshahi</name></author><author><name sortKey="Barclay, An" uniqKey="Barclay A">AN Barclay</name></author><author><name sortKey="Brown, Mh" uniqKey="Brown M">MH Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mihrshahi, R" uniqKey="Mihrshahi R">R Mihrshahi</name></author><author><name sortKey="Brown, Mh" uniqKey="Brown M">MH Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wright, Gj" uniqKey="Wright G">GJ Wright</name></author><author><name sortKey="Cherwinski, H" uniqKey="Cherwinski H">H Cherwinski</name></author><author><name sortKey="Foster Cuevas, M" uniqKey="Foster Cuevas M">M Foster-Cuevas</name></author><author><name sortKey="Brooke, G" uniqKey="Brooke G">G Brooke</name></author><author><name sortKey="Puklavec, Mj" uniqKey="Puklavec M">MJ Puklavec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mukhopadhyay, S" uniqKey="Mukhopadhyay S">S Mukhopadhyay</name></author><author><name sortKey="Pluddemann, A" uniqKey="Pluddemann A">A Pluddemann</name></author><author><name sortKey="Hoe, Jc" uniqKey="Hoe J">JC Hoe</name></author><author><name sortKey="Williams, Kj" uniqKey="Williams K">KJ Williams</name></author><author><name sortKey="Varin, A" uniqKey="Varin A">A Varin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deckert, M" uniqKey="Deckert M">M Deckert</name></author><author><name sortKey="Sedgwick, Jd" uniqKey="Sedgwick J">JD Sedgwick</name></author><author><name sortKey="Fischer, E" uniqKey="Fischer E">E Fischer</name></author><author><name sortKey="Schluter, D" uniqKey="Schluter D">D Schluter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cortez, M" uniqKey="Cortez M">M Cortez</name></author><author><name sortKey="Huynh, C" uniqKey="Huynh C">C Huynh</name></author><author><name sortKey="Fernandes, Mc" uniqKey="Fernandes M">MC Fernandes</name></author><author><name sortKey="Kennedy, Ka" uniqKey="Kennedy K">KA Kennedy</name></author><author><name sortKey="Aderem, A" uniqKey="Aderem A">A Aderem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karnam, G" uniqKey="Karnam G">G Karnam</name></author><author><name sortKey="Rygiel, Tp" uniqKey="Rygiel T">TP Rygiel</name></author><author><name sortKey="Raaben, M" uniqKey="Raaben M">M Raaben</name></author><author><name sortKey="Grinwis, Gc" uniqKey="Grinwis G">GC Grinwis</name></author><author><name sortKey="Coenjaerts, Fe" uniqKey="Coenjaerts F">FE Coenjaerts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shlapatska, Lm" uniqKey="Shlapatska L">LM Shlapatska</name></author><author><name sortKey="Mikhalap, Sv" uniqKey="Mikhalap S">SV Mikhalap</name></author><author><name sortKey="Berdova, Ag" uniqKey="Berdova A">AG Berdova</name></author><author><name sortKey="Zelensky, Om" uniqKey="Zelensky O">OM Zelensky</name></author><author><name sortKey="Yun, Tj" uniqKey="Yun T">TJ Yun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurt Jones, Ea" uniqKey="Kurt Jones E">EA Kurt-Jones</name></author><author><name sortKey="Sandor, F" uniqKey="Sandor F">F Sandor</name></author><author><name sortKey="Ortiz, Y" uniqKey="Ortiz Y">Y Ortiz</name></author><author><name sortKey="Bowen, Gn" uniqKey="Bowen G">GN Bowen</name></author><author><name sortKey="Counter, Sl" uniqKey="Counter S">SL Counter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="St Leger, Aj" uniqKey="St Leger A">AJ St Leger</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B Peters</name></author><author><name sortKey="Sidney, J" uniqKey="Sidney J">J Sidney</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A Sette</name></author><author><name sortKey="Hendricks, Rl" uniqKey="Hendricks R">RL Hendricks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheridan, Bs" uniqKey="Sheridan B">BS Sheridan</name></author><author><name sortKey="Cherpes, Tl" uniqKey="Cherpes T">TL Cherpes</name></author><author><name sortKey="Urban, J" uniqKey="Urban J">J Urban</name></author><author><name sortKey="Kalinski, P" uniqKey="Kalinski P">P Kalinski</name></author><author><name sortKey="Hendricks, Rl" uniqKey="Hendricks R">RL Hendricks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Tj" uniqKey="Taylor T">TJ Taylor</name></author><author><name sortKey="Mcnamee, Ee" uniqKey="Mcnamee E">EE McNamee</name></author><author><name sortKey="Day, C" uniqKey="Day C">C Day</name></author><author><name sortKey="Knipe, Dm" uniqKey="Knipe D">DM Knipe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boudakov, I" uniqKey="Boudakov I">I Boudakov</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Fan, N" uniqKey="Fan N">N Fan</name></author><author><name sortKey="Gulay, P" uniqKey="Gulay P">P Gulay</name></author><author><name sortKey="Wong, K" uniqKey="Wong K">K Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, Jl" uniqKey="Young J">JL Young</name></author><author><name sortKey="Mora, A" uniqKey="Mora A">A Mora</name></author><author><name sortKey="Cerny, A" uniqKey="Cerny A">A Cerny</name></author><author><name sortKey="Czech, Mp" uniqKey="Czech M">MP Czech</name></author><author><name sortKey="Woda, B" uniqKey="Woda B">B Woda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcginnes, Lw" uniqKey="Mcginnes L">LW McGinnes</name></author><author><name sortKey="Gravel, Ka" uniqKey="Gravel K">KA Gravel</name></author><author><name sortKey="Finberg, Rw" uniqKey="Finberg R">RW Finberg</name></author><author><name sortKey="Kurt Jones, Ea" uniqKey="Kurt Jones E">EA Kurt-Jones</name></author><author><name sortKey="Massare, Mj" uniqKey="Massare M">MJ Massare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mariathasan, S" uniqKey="Mariathasan S">S Mariathasan</name></author><author><name sortKey="Weiss, Ds" uniqKey="Weiss D">DS Weiss</name></author><author><name sortKey="Newton, K" uniqKey="Newton K">K Newton</name></author><author><name sortKey="Mcbride, J" uniqKey="Mcbride J">J McBride</name></author><author><name sortKey="O Ourke, K" uniqKey="O Ourke K">K O’Rourke</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hornung, V" uniqKey="Hornung V">V Hornung</name></author><author><name sortKey="Ablasser, A" uniqKey="Ablasser A">A Ablasser</name></author><author><name sortKey="Charrel Dennis, M" uniqKey="Charrel Dennis M">M Charrel-Dennis</name></author><author><name sortKey="Bauernfeind, F" uniqKey="Bauernfeind F">F Bauernfeind</name></author><author><name sortKey="Horvath, G" uniqKey="Horvath G">G Horvath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rathinam, Va" uniqKey="Rathinam V">VA Rathinam</name></author><author><name sortKey="Jiang, Z" uniqKey="Jiang Z">Z Jiang</name></author><author><name sortKey="Waggoner, Sn" uniqKey="Waggoner S">SN Waggoner</name></author><author><name sortKey="Sharma, S" uniqKey="Sharma S">S Sharma</name></author><author><name sortKey="Cole, Le" uniqKey="Cole L">LE Cole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muruve, Da" uniqKey="Muruve D">DA Muruve</name></author><author><name sortKey="Petrilli, V" uniqKey="Petrilli V">V Petrilli</name></author><author><name sortKey="Zaiss, Ak" uniqKey="Zaiss A">AK Zaiss</name></author><author><name sortKey="White, Lr" uniqKey="White L">LR White</name></author><author><name sortKey="Clark, Sa" uniqKey="Clark S">SA Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vollstedt, S" uniqKey="Vollstedt S">S Vollstedt</name></author><author><name sortKey="Franchini, M" uniqKey="Franchini M">M Franchini</name></author><author><name sortKey="Alber, G" uniqKey="Alber G">G Alber</name></author><author><name sortKey="Ackermann, M" uniqKey="Ackermann M">M Ackermann</name></author><author><name sortKey="Suter, M" uniqKey="Suter M">M Suter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author><author><name sortKey="Pasieka, Tj" uniqKey="Pasieka T">TJ Pasieka</name></author><author><name sortKey="Leib, Da" uniqKey="Leib D">DA Leib</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Detje, Cn" uniqKey="Detje C">CN Detje</name></author><author><name sortKey="Meyer, T" uniqKey="Meyer T">T Meyer</name></author><author><name sortKey="Schmidt, H" uniqKey="Schmidt H">H Schmidt</name></author><author><name sortKey="Kreuz, D" uniqKey="Kreuz D">D Kreuz</name></author><author><name sortKey="Rose, Jk" uniqKey="Rose J">JK Rose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eidson, Km" uniqKey="Eidson K">KM Eidson</name></author><author><name sortKey="Hobbs, We" uniqKey="Hobbs W">WE Hobbs</name></author><author><name sortKey="Manning, Bj" uniqKey="Manning B">BJ Manning</name></author><author><name sortKey="Carlson, P" uniqKey="Carlson P">P Carlson</name></author><author><name sortKey="Deluca, Na" uniqKey="Deluca N">NA DeLuca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perry, Ak" uniqKey="Perry A">AK Perry</name></author><author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name></author><author><name sortKey="Zheng, D" uniqKey="Zheng D">D Zheng</name></author><author><name sortKey="Tang, H" uniqKey="Tang H">H Tang</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tabeta, K" uniqKey="Tabeta K">K Tabeta</name></author><author><name sortKey="Georgel, P" uniqKey="Georgel P">P Georgel</name></author><author><name sortKey="Janssen, E" uniqKey="Janssen E">E Janssen</name></author><author><name sortKey="Du, X" uniqKey="Du X">X Du</name></author><author><name sortKey="Hoebe, K" uniqKey="Hoebe K">K Hoebe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hochrein, H" uniqKey="Hochrein H">H Hochrein</name></author><author><name sortKey="Schlatter, B" uniqKey="Schlatter B">B Schlatter</name></author><author><name sortKey="O Eeffe, M" uniqKey="O Eeffe M">M O’Keeffe</name></author><author><name sortKey="Wagner, C" uniqKey="Wagner C">C Wagner</name></author><author><name sortKey="Schmitz, F" uniqKey="Schmitz F">F Schmitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lund, J" uniqKey="Lund J">J Lund</name></author><author><name sortKey="Sato, A" uniqKey="Sato A">A Sato</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S Akira</name></author><author><name sortKey="Medzhitov, R" uniqKey="Medzhitov R">R Medzhitov</name></author><author><name sortKey="Iwasaki, A" uniqKey="Iwasaki A">A Iwasaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davey, Gm" uniqKey="Davey G">GM Davey</name></author><author><name sortKey="Wojtasiak, M" uniqKey="Wojtasiak M">M Wojtasiak</name></author><author><name sortKey="Proietto, Ai" uniqKey="Proietto A">AI Proietto</name></author><author><name sortKey="Carbone, Fr" uniqKey="Carbone F">FR Carbone</name></author><author><name sortKey="Heath, Wr" uniqKey="Heath W">WR Heath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koning, N" uniqKey="Koning N">N Koning</name></author><author><name sortKey="Swaab, Df" uniqKey="Swaab D">DF Swaab</name></author><author><name sortKey="Hoek, Rm" uniqKey="Hoek R">RM Hoek</name></author><author><name sortKey="Huitinga, I" uniqKey="Huitinga I">I Huitinga</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mott, Kr" uniqKey="Mott K">KR Mott</name></author><author><name sortKey="Underhill, D" uniqKey="Underhill D">D Underhill</name></author><author><name sortKey="Wechsler, Sl" uniqKey="Wechsler S">SL Wechsler</name></author><author><name sortKey="Town, T" uniqKey="Town T">T Town</name></author><author><name sortKey="Ghiasi, H" uniqKey="Ghiasi H">H Ghiasi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Lint, Al" uniqKey="Van Lint A">AL van Lint</name></author><author><name sortKey="Murawski, Mr" uniqKey="Murawski M">MR Murawski</name></author><author><name sortKey="Goodbody, Re" uniqKey="Goodbody R">RE Goodbody</name></author><author><name sortKey="Severa, M" uniqKey="Severa M">M Severa</name></author><author><name sortKey="Fitzgerald, Ka" uniqKey="Fitzgerald K">KA Fitzgerald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Semmling, V" uniqKey="Semmling V">V Semmling</name></author><author><name sortKey="Lukacs Kornek, V" uniqKey="Lukacs Kornek V">V Lukacs-Kornek</name></author><author><name sortKey="Thaiss, Ca" uniqKey="Thaiss C">CA Thaiss</name></author><author><name sortKey="Quast, T" uniqKey="Quast T">T Quast</name></author><author><name sortKey="Hochheiser, K" uniqKey="Hochheiser K">K Hochheiser</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Soberman, Roy J" sort="Soberman, Roy J" uniqKey="Soberman R" first="Roy J." last="Soberman">Roy J. Soberman</name></region><name sortKey="Aronov, Lisa" sort="Aronov, Lisa" uniqKey="Aronov L" first="Lisa" last="Aronov">Lisa Aronov</name><name sortKey="Cerny, Anna M" sort="Cerny, Anna M" uniqKey="Cerny A" first="Anna M." last="Cerny">Anna M. Cerny</name><name sortKey="Christmas, Peter" sort="Christmas, Peter" uniqKey="Christmas P" first="Peter" last="Christmas">Peter Christmas</name><name sortKey="Knipe, David M" sort="Knipe, David M" uniqKey="Knipe D" first="David M." last="Knipe">David M. Knipe</name><name sortKey="Kurt Jones, Evelyn A" sort="Kurt Jones, Evelyn A" uniqKey="Kurt Jones E" first="Evelyn A." last="Kurt-Jones">Evelyn A. Kurt-Jones</name><name sortKey="Mackay, Christopher R" sort="Mackay, Christopher R" uniqKey="Mackay C" first="Christopher R." last="Mackay">Christopher R. Mackay</name><name sortKey="Nikolic, Boris" sort="Nikolic, Boris" uniqKey="Nikolic B" first="Boris" last="Nikolic">Boris Nikolic</name><name sortKey="Primo, Valeria" sort="Primo, Valeria" uniqKey="Primo V" first="Valeria" last="Primo">Valeria Primo</name><name sortKey="Ryan, Glennice Bowen" sort="Ryan, Glennice Bowen" uniqKey="Ryan G" first="Glennice Bowen" last="Ryan">Glennice Bowen Ryan</name><name sortKey="Sheiffele, Paul" sort="Sheiffele, Paul" uniqKey="Sheiffele P" first="Paul" last="Sheiffele">Paul Sheiffele</name><name sortKey="Thompson, Mikayla R" sort="Thompson, Mikayla R" uniqKey="Thompson M" first="Mikayla R." last="Thompson">Mikayla R. Thompson</name><name sortKey="Vaine, Christine A" sort="Vaine, Christine A" uniqKey="Vaine C" first="Christine A." last="Vaine">Christine A. Vaine</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B83 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B83 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3474780
|texte= CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23082204" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |